Efficiency of Phosphemide Employment at Increasing the Productivity of the Candida maltosa Tm-12 Strain

About the authors:

Irina V. Pak, Dr. Sci. (Biol.), Professor, Head of the Department of Ecology and Genetics, University of Tyumen; pakiv57@mail.ru

Oleg V. Trofimov, Cand. Sci. (Biol.), Assistant Professor, Department of Ecology and Genetics, University of Tyumen; oleg_v_trofimov@mail.ru

Larisa I. Weisfeld, Ph. D., Senior Researcher, N. M  Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences (Moscow); liv11@yandex.ru

Rizvan D. Rustamov, Postgraduate Student, Department of Ecology and Genetics, University of Tyumen; kafedraekogen@mail.ru

Ksenia V. Skvortsova, Postgraduate Student, Department of Ecology and Genetics, University of Tyumen; kafedraekogen@mail.ru

Abstract:

A new way of increasing the productivity of the Candida maltosa Tm-12 yeast strain using phosphemide was invented. Phosphemide was developed at the All-Union Scientific Research Chemical-Pharmaceutical Institute and proposed as a cytostatic agent that suppresses the proliferation of tumor cells. Its mutagenic effect was demonstrated on the cultures of human and mouse fibroblasts, and on several plant species. The impact of various concentrations of phosphemide (0.1; 0.01; 0.001, and 0.0001%) on the Candida maltosa Tm-12 yeasts was examined. The research showed that the studied concentrations of phosphemide affect both the number and sizes of building up colonies. An effective phosphemide concentration providing 1,08 more increase in biomass than in the control was established. It was also shown that the studied concentrations of phosphemide bear no effect on the Candida maltosa Tm-12 protein composition.

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