Simulating effect of low intensity temperature actions on psycho-neuro-immuno-endocrine system of warm-blooded organisms

About the authors:

Ivan M. Besedin, Researcher, Tyumen Scientific Center, Siberian Branch of the Russian Academy of Sciences; teriolog@mail.ru

Alexander S. Bazhin, Researcher, Department of Cryosphere Bioresources, Tyumen Scientific Center, Siberian Branch of the Russian Academy of Sciences; aleksandrbazhin@mail.ru

Vladimir P. Melnikov, Dr. Sci. (Geol-Mineral.), Academician of the Russian Academy of Sciences, Chairman of the Tyumen Scientific Center, Siberian Branch of the Russian Academy of Sciences; melnikov@ikz.ru

Lyudmila F. Kalenova, Dr. Sci. (Biol.), Chief Researcher, Department of Bioresources Сryosphere, Tyumen Scientific Centre of the Siberian Branch of the Russian Academy of Sciences; Leading Researcher, International Center of Cryology and Cryosophy, University of Tyumen; lkalenova@mail.ru

Abstract:

The study has been performed in mice BALB/c, weighing 20-22 g. Tertsik (DNA Technology, Russia) programmable thermoelectric device with a temperature module S=1 cm2 affected the chest locally. The authors use three impact programs: + 8 ºC module temperature, 5 seconds duration (“Cold”); + 42 ºC, 30 seconds (“Warmth”); + 33 ° C, 15 seconds (“Control stress”). It is found that the low intensity temperature actions can cause systemic reactions in warm-blooded animals to activate the central nervous system, to modulate the emotional state of animals, to change muscle activity, to influence the food instinct and effector mechanisms of the immune system. Thus, when low temperature (“Cold”), the right hemisphere of the brain is activating mainly, muscle activity and animal food instinct are increasing, the immune system predominantly with Th1-dependent (pro-inflammatory) immune response is increasing. When high temperature (“Warmth”), muscle activity is decreasing moderately, food instinct is suppressing, the stimulation of the immune system with predominantly Th2-dependent (anti-inflammatory) immune response is decreasing. Short-term local exposure to cold activates katatoxic orientation of adaptive response and the functional activity of cellular immunity without humoral immune activity suppression. 
Short-term local effects of heat activate sintooxic orientation of adaptive response and the functional activity of humoral immunity without reducing the activity of cellular immunity. Thus, the temperature effects of low intensity are capable to modulate the activity of the nervous, immune and endocrine regulatory systems as well as to influence the psycho-emotional condition of the animals. It evaluates the idea of thermoregulation system as a “super-system” in the organismic architectonics.

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