The state of blood system under controlled hyperthermia in experiments

About the author:

Vladimir S. Solovyov, Dr. Sci. (Med.), Professor, Head of the Department of Anatomy and Physiology of Humans and Animals, Institute of Biology, Tyumen State University; adapt78@yandex.ru

Abstract:

Controlled hyperthermia is a perspective method to treat oncologic and other pathologies. The role of blood system in securing its congenital protective properties of nonspecific resistance and anti-hypoxic mechanisms under hyperthermia are studied insufficiently. This article describes the results of acute and chronic experiments in dogs under anesthesia and without it and rabbits under controlled hyperthermia with body temperature of 42°С. The direct effects at rehabilitation period were studied. Quantities and functional parameters of red and white blood were detected. Morphological and functional properties of single leukocyte or erythrocyte were studied. The experiments with use of chrome isotopes and gold were aimed to examine redistributive blood reaction, circulating blood volume, absorbing isotopes by internal organs, the properties of reticuloendothelial system. The role of mast basophilic system and toxic serum properties of healthy and overheated animals are studied. The oxygen and carbon dioxide transport, acid basic balance, oxygen affinity to hemoglobin are defined. The quick reactions of bone marrow are registered; the myelogram fixed the increase of monocytes and megacaryocytes. The leucogram indicated the prevalence of activation reactions.The general organism answer under heat influence activates the syndrome of hematologic stress. It proves A. A. Bogomolets’ theory about an integrative function of active mesenchyma and blood system in adaptive mechanism of organism under hyperthermia.

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