Responsiveness of peripheral erythron in children with inflammatory respiratory system

UT Research Journal. Natural Resource Use and Ecology


Release:

2015, Vol. 1. №4(4)

Title: 
Responsiveness of peripheral erythron in children with inflammatory respiratory system


About the authors:

Sergey L. Sashenkov, Dr Sci. (Med.), Professor, Normal physiology Department, South Ural State Medical University (Chelyabinsk)
Larisa V. Alacheva, Assistant, Normal physiology Department, South Ural State Medical University (Chelyabinsk)

Abstract:

Peripheral erythron in the children with inflammatory diseases of respiratory system responds to hypoxia and inflammation. The study involved 120 children at the age of 1 to 6 years, admitted to pulmonology with diagnoses: pneumonia, acute obstructive bronchitis or recurrent obstructive, acute nonobstructive bronchitis or recurrent, infectious and inflammatory diseases of the upper respiratory tract in the acute phase of the disease, sickly children. It has been found out that functional properties of erythrocytes significantly changed in the children with inflammatory diseases of respiratory system. Red blood cells are actively involved in the pathological process, which is manifested in damage to erythrocyte membranes, increasing their permeability and the change in electrokinetic properties, violation of erythrocytes energy metabolism. Functional state of erythrocytes depends on the course of inflammatory process. And in the early stages, the changes relate to the functional state of erythrocyte membranes and metabolism; quantitative indicators change later.

References:

1.             Albitsky V. Yu., Baranov A. A., Kamaev I. A., Ogneva M. L. Chasto boleyuschie deti [Sickly Children]. Nizhniy Novgorod: Izdatelstvo Nizhegorodskoy gosudarstvennoy medicinskoy akademii [Nizhny Novgorod State Medical Academy Publishing], 2003.
180 p. (In Russian)

2.             Gitelzon I. I., Terskov I. A. Eritrogrammy kak metod klinicheskogo issledovaniya krovi [Erythrograms as a Method of Clinical Blood Study]. Krasnoyarsk, 1959. 233 p. (In Russian)

3.             Kaganov S. Yu. Sovremennye problemy pulmonologii detskogo vozrasta [Modern Problems of Children Pulmonology] // Rossiyskiy vestnik perinatologii i pediatrii [Russian Herald of Perinatology and Pediatrics]. 2003. Vol. 48. No 3. Pp. 9-16. (In Russian)

4.             Krylov V. N., Deryugina A. V. Tipovye izmeneniya elektroforeticheskoy podvizhnosti eritrocitov pri stressovyh vozdeystviyah [Typical Changes in the Electrophoretic Mobility of Erythrocytes Under Stress] // Byulleten eksperimentalnoy biologii i mediciny [Bulletin of Experimental Biology and Medicine]. 2005. Vol. 139. No 4. Pp. 364-366. (In Russian)

5.             Kuznik B. I. Eritrocity i gemoreologiya [Erythrocytes and Hemorheology] // Problemy klinicheskoy mediciny [Problems of Clinical Medicine]. 2010. No 1. Pp. 108-124. (In Russian)

6.             Mizernitsky Yu. L., Melnikova I. M. Chastye ostrye respiratornye zabolevaniya u detey: sovremennye predstavleniya [Frequent Acute Respiratory Infections in Children: Modern Concepts] // Rossiyskiy vestnik perinatologii i pediatrii [Russian Herald of Perinatology and Pediatrics]. 2009. Vol. 54. No 3. Pp. 7-13. (In Russian)

7.             Mikhailovich V. A., Marusanov V. E., Bichun A. B. Pronicaemost eritrocitarnyh membran i sorbcionnaya sposobnost eritrocitov optimalnye kriterii tyazhesti endogennoy intoksikacii [Erythrocyte Membrane Permeability and Their Sorption Capacity: Optimal Criteria for Severity of Endogenous Intoxication] // Anesteziologiya i reanimatologiya [Anesthesiology and Critical Care Medicine]. 1993. No 5. Pp. 66-69. (In Russian)

8.             Stepovaya E. A., Novitsky V. V., Ryazantseva N. V. Tipovye izmeneniya eritrocitov pri hronicheskom vospalenii [Typical Erythrocytes Changes Under Chronic Inflammation] // Byulleten eksperimentalnoy biologii i mediciny [Bulletin of Experimental Biology and Medicine]. 2004. Vol. 137. No 1. Pp. 66-70. (In Russian)

9.             Sudakov K. V., Zakharov Yu. M. Funkcionalnaya sistema, opredelyayuschaya optimalnyy uroven eritrocitov v organizme [Functional System, Determining the Optimal Erythrocyte Level in the Organism] // Klinicheskaya medicina [Clinical Medicine]. 2002. Vol. 80.  No 4. Pp. 4-11. (In Russian)

10.         Togaibayev A. A., Kurguzkin A. V., Rikun I. V. Sposob diagnostiki endogennoy intoksikacii [A Method to Diagnose Endogenous Intoxication] // Laboratornoe delo [Laboratory Science]. 1988. No 9. Pp. 22-24. (In Russian)

11.         Chirkin A. A., Romanovsky R. V., Solovyov Yu. A. Diagnosticheskaya cennost opredeleniya intensivnosti pentozofosfatnogo puti obmena uglevodov v eritrocitah [Diagnostic Value of Detecting the Intensity of the Pentose Phosphate Pathway of Carbohydrate Metabolism in Erythrocytes] // Laboratornoe delo [Laboratory Science]. 1983. No 11. Pp. 39-42 (In Russian)