The influence of the isoflurane-based anesthesia components on oxidative metabolism of lipids, erythrocytes and blood plasma in cardiac suregy

About the authors:

Sergey L. Galyan, Dr. Sci. (Med.), Professor, Head of the Department of Biochemistry, Tyumen State Medical Academy
Tatiana Yu. Il'inykh, Cand. Sci. (Biol.), Assistant, Department of Biochemistry, Tyumen State Medical Academy
Danil Yu. Kadochnikov, Post-graduate Student, Department of Cybernetic Technologies, Tyumen State Oil and Gas University
Vladimir G. Popov, Cand. Sci. (Sociol.), Head of the Department of Commodity and Food Technology, Tyumen State Oil and Gas University

Abstract:

The study on the effect of isoflurane on the POL-AOP system (lipid peroxidation — antioxidant protection) encompasses 36 patients with CHD (coronary heart disease) who underwent CABG (coronary artery bypass grafting) surgery. The patients did not differ in the functional class of heart failure, angina, and comorbidities. The anesthetic management of the operation was performed by one protocol based on isoflurane; duration periods of the pre-perfusion and perfusion in the patients were comparable. The CABG surgery has been accompanied by disturbances in the LPO-AOD erythrocytes and plasma, which was confirmed by the oppositely directed changes (increase or decrease) in DC performance, oxidation rate, AOP, AL, PL and cholesterol levels during the stages of the study. The highest intensity of the process of lipid peroxidation is registered at the pre-perfusion stage. The membrane-trophic and preconditioning effect of isoflurane increases the blood lipids resistance to peroxidation during assisted circulation and the early postoperative period. Inhibition of lipid peroxidation process and improvement of the cholesterol-synthesizing liver function during assisted circulation indicates adequate anesthetic protection.

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