Osteoporosis and cardiovascular pathology: peculiarities of the combined disease development

Tyumen State University Herald. Natural Resource Use and Ecology


Release:

Bulletin of Tyumen State University. Medico-Biological Sciences (№6). 2013

Title: 
Osteoporosis and cardiovascular pathology: peculiarities of the combined disease development


About the authors:

Tatiana V. Bolotnova , Dr. Med. Sci., Head of the Department of Internal Medicine,
Outpatient Therapy and Family Medicine, Tyumen State Medical Academy

Natalia G. Platitsyna, Cand. Med. Sci., Associate Professor, Department of Internal
Medicine, Outpatient Therapy and Family Medicine, Tyumen State Medical Academy

Olga N. Kuslivaya, Assistant, Department of Internal Medicine, Outpatient Therapy
and Family Medicine, Tyumen State Medical Academy

Abstract:

The article presents the research data devoted to the features of the associated course of coronary heart disease (CHD), arterial hypertension (AH) and osteoporosis (OP). The research covered 82 patients with CHD and AH of mature and senior age and 28 persons in the control group. Analysis of osteoporosis risk factors was carried out on the basis of the unified questionnaires; computer program FRAX was employed. We have proved that osteoporosis risk factors were more typical of the patients with cardiovascular pathology in comparison with healthy people. The risk of osteoporotic fractures was much higher regarding the patients with cardiovascular diseases which in most cases allows to initiate treatment. On the basis of a complex clinic-functional research based on the results of bone densitometry, frequency of occurrence of osteopenic syndrome among the patients with cardiovascular pathology was determined. Patients with coronary heart disease in association with arterial hypertension demonstrated the syndrome of osteopenia in 57,5+9,01% of cases (osteoporosis 35,0+5,45%, osteopenia — 22,5+3,47%); for the patients with AH heh index is 45,23+0,07% (4,76+0,65% and 40,47+6,16%, respectively); in the control group there were only 17,85+3,27% cases of osteopenia. The lowest indicators of mineral density of bones are registered among the patients with coronary heart disease in association with arterial hypertension, and practically half of the patients had a severe acute form of the disease. The obtained data testify to the need of complex prevention and timely diagnostics of the osteopenic syndrome among the patients with cardiovascular pathology.

References:

1. Osteoporoz: Diagnostika, profilaktika i lechenie. Klinicheskie rekomendacii

[Osteoporosis: Diagnostics, Prevention, and Treatment. Clinical Recommendations / Ed. by О.М. Lesnyak, L.I. Benevolenskaya. 2-nd edition, amended and improved]. Moscow: GEOTARMedia, 2009. 272 p. (in Russian).

2. Jalava, T., Sarna, S., Pylkkänen, L., Mawer, B. et al. Association between vertebral

fracture and increased mortality in osteoporotic patients. J. Bone. Miner. Res. 2003. Vol. 18(7). Р. 1254-1260.

3. Hasserius, R, Karlsson, MK, Nilsson, BE et al. Prevalent vertebral deformities predict

increased mortality and increased fracture rate in both men and women: a 10-year populationbased study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study. Osteoporosis Int., 2003. Vol. 14(1). Р.61-68.

4. Naves, M., Diaz-Lopez, J.B., Gomez, C., et al. The effect of vertebral fracture as a risk

factor for osteoporotic fracture and mortality in a Spanish population. Osteoporosis Int.

2003. Vol. 14. Р. 520–524.

5. Ensrud, K.E., Thompson, D.E., Cauley, J.A. et al. Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture intervention trial research group. Journal of the American Geriatrics Society. 2000. Vol. 48(3). Р. 241-249.

6. Tankoґ, L.B., Bagger, Y.Z., Christiansen. Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcified Tissue International. 2003. Vol. 73. Р. 15-20.

7. Browner, W.S., Sooley, D.G., Vogt, T.M. Non-trauma mortality in eldery women with low bone mineral density. Lancet. 1991. Vol. 338. Р. 335-338.

8. Browner, W.S., Pressman, A.R., Nevitt, M.C. et al. Association between low density and stroke in eldery women. Stroke. 1993. Vol. 24(7). Р. 940-946.

9. Tankó, LB, Christiansen, C., Cox, D.A. et al. Relationship between osteoporosis and

cardiovascular disease in postmenopausal women. J. Bone. Miner. Res. 2005. Vol. 20(11). Р. 1912-1920. Erratum in: J. Bone. Miner. Res. 2006. Vol. 21(2). Р. 352.

10. Uyama, O., Yoshimoto, Y., Yamamoto, Y., Kawai, A. Bone changes and carotid

atherosclerosis in postmenopausal women. Stroke. 1997. Vol. 28(9). Р. 1730-1732.

11. Recke, P. van, Hansen, M.A., Hassager, C. The association between low bone mass at the menopause and cardiovascular mortality. Am. J. Med. 1999. Vol. 106(3). Р. 273-278.

12. Marcovitz, P.A., Tran, H.H., Franklin, B.A., O’Neill, W.W., Yerkey, M., Boura, J.,

Kleerkoper, M., Dickinson, C.Z. Usefulness of bone mineral density to predict significant

coronary artery disease. Am. J. Cardiol. 2005. Vol. 96 (8). Р. 1059–1063.

13. Shanahan, C.M. et al. High expression of genes for calcification-regulating proteins in human atherosclerotic plaque. J. Clin. Invest. 1994. Vol. 93(6). Р. 2393–2402.

14. Giachelli, C.M., Bae, N., Almeida, M. et al. Osteopontin is elevated during neointima

formation in rat arteries and is a novel component of human atherosclerotic plaque.

J. Clin. Invest. 1993. Vol. 92(4). Р. 1686–1696.

15. Sasaki, T., Hong, M. H. Endothelin-1 localization in bone cells and vascular endothelial cells in rat bone marrow. Anat. Rec. 1993. Vol. 237(3). Р. 332-337.

16. Stimpel, M., Jee, W.S.S., Ma, Y., Yamamoto, N., Chen, Y. Impact of antihypertensive therapy on postmenopausal osteoporosis: Effects of the angiotensin converting enzyme inhibitor moexipril, 17β-estradiol and their combination on the ovariectomy-induced cancellous bone loss in young rats. Journal of Hypertension. 1995. Vol. 13(12). Р. 1852–1856.

17. Hatton, R., Stimpell, M., Chambers, T.J. Angiotensin II is generated from angiotensin

I by bone cells and stimulates osteoclastic bone resorption in vitro. J. Endocrinol. 1997.

Vol. 152(1). Р. 5-10.

18. WHO Study Group. 1994. Assessment of fracture risk and its application to

postmenopausal osteoporosis. World Health Organization Technical Report Series No. 843